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The consumption of a MD has also been associated with better quality of semen in observational studies, but further interventional studies in this area are required to determine whether it may contribute to a higher chance of positive pregnancy outcomes [83,88,89,90]

Taken together, these findings emphasize that target selection is ultimately a systems-level decision, where integrating molecular evidence, disease-class specificity, expression context, and historical maturity provides a more robust framework than relying on any single metric alone